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Targeted Allele Detail
Symbol: Acvr2btm1.1Spo
Name: activin receptor IIB; targeted mutation 1.1, S Paul Oh
MGI ID: MGI:3697600
Synonyms: Acvr2b4
Gene: Acvr2b  Location: Chr9:119402444-119433501 bp, + strand  Genetic Position: Chr9, 71.33 cM
Germline Transmission:  Earliest citation of germline transmission: J:114533
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA targeting vector was designed to insert a modified exon 4 such that it was fused to exon 3 as well as a floxed neo cassette that was inserted into exon 4. The neo cassette was then removed by mating with Tg(ACTB-cre)2Mrt mice. (J:114533)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acvr2b Mutation:  5 strains or lines available
Original:  J:114533 Lee YJ, et al., Generation of activin receptor type IIB isoform-specific hypomorphic alleles. Genesis. 2006 Oct;44(10):487-94
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory