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Abca2tm1Kdt
Targeted Allele Detail
Nomenclature
Symbol: Abca2tm1Kdt
Name: ATP-binding cassette, sub-family A (ABC1), member 2; targeted mutation 1, Kenneth D Tew
MGI ID: MGI:3697467
Synonyms: Abca2-
Gene: Abca2  Location: Chr2:25428703-25448540 bp, + strand  Genetic Position: Chr2, 17.25 cM, cytoband A2-B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:117673
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 23-30 were replaced with a neomycin resistance cassette. This sequence encoded the first nucleotide binding domain. (J:117673)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Abca2 Mutation:  40 strains or lines available
References
Original:  J:117673 Mack JT, et al., 'Skittish' Abca2 knockout mice display tremor, hyperactivity, and abnormal myelin ultrastructure in the central nervous system. Mol Cell Biol. 2007 Jan;27(1):44-53
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/13/2017
MGI 6.10
The Jackson Laboratory