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Hrctm1Blk
Targeted Allele Detail
Nomenclature
Symbol: Hrctm1Blk
Name: histidine rich calcium binding protein; targeted mutation 1, Brian L Black
MGI ID: MGI:3697445
Gene: Hrc  Location: Chr7:45335290-45338974 bp, + strand  Genetic Position: Chr7, 29.26 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:117648
Parent Cell Line:  KG-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced exon 1. Lack of protein was confrmed by immunoblotting of mutant heart and skeletal muscle. (J:117648)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hrc Mutation:  15 strains or lines available
References
Original:  J:117648 Jaehnig EJ, et al., Increased susceptibility to isoproterenol-induced cardiac hypertrophy and impaired weight gain in mice lacking the histidine-rich calcium-binding protein. Mol Cell Biol. 2006 Dec;26(24):9315-26
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory