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QTL Variant Detail
QTL variant: Char2aC57BL/6J
Name: P. chabaudi malaria resistance QTL 2a; C57BL/6J
MGI ID: MGI:3697103
QTL: Char2a  Location: Chr8:71136783-90202598 bp  Genetic Position: Chr8, Syntenic
Strain of Specimen:  C57BL/6J
Allele Type:    QTL

Mapping and Phenotype information for this QTL, its variants and associated markers


Congenic line analysis was used to refine the Char2 locus on mouse Chromosome 8. Nine recombinant congenic strains were created by repeatedly backcrossing B6.C3-Char2 to parental strain C57BL/6J. Animals from each subcongenic line were tested for malariaresistance by injection with red blood cells infected with Plasmodium chabaudi. The Char2 region appears to harbor 2 separate QTLs, designated Char2a and Char2b. Char2a is located between D8Mit27a (33 cM) and D8Mit266 (43 cM). Char2b is located between D8Mit14 (67 cM) and D8Mit56 (73 cM). C3H/HeJ-derived alleles at Char2a and Char2b appear to confer susceptibility to malaria.

Original:  J:117548 Lin E, et al., Mapping of the Plasmodium chabaudi resistance locus char2. Infect Immun. 2006 Oct;74(10):5814-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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