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Char2aC57BL/6J
QTL Variant Detail
Nomenclature
QTL variant: Char2aC57BL/6J
Name: P. chabaudi malaria resistance QTL 2a; C57BL/6J
MGI ID: MGI:3697103
QTL: Char2a  Location: Chr8:71136783-90202598 bp  Genetic Position: Chr8, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:117548

Congenic line analysis was used to refine the Char2 locus on mouse Chromosome 8. Nine recombinant congenic strains were created by repeatedly backcrossing B6.C3-Char2 to parental strain C57BL/6J. Animals from each subcongenic line were tested for malariaresistance by injection with red blood cells infected with Plasmodium chabaudi. The Char2 region appears to harbor 2 separate QTLs, designated Char2a and Char2b. Char2a is located between D8Mit27a (33 cM) and D8Mit266 (43 cM). Char2b is located between D8Mit14 (67 cM) and D8Mit56 (73 cM). C3H/HeJ-derived alleles at Char2a and Char2b appear to confer susceptibility to malaria.

References
Original:  J:117548 Lin E, et al., Mapping of the Plasmodium chabaudi resistance locus char2. Infect Immun. 2006 Oct;74(10):5814-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory