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Transgene Detail
Symbol: Tg(CAG-Bgeo,-Tle1,-ALPP)1Lbe
Name: transgene insertion 1, Corrinne Lobe
MGI ID: MGI:3696852
Synonyms: Grg1 conditional transgene, Grg1lacZ, iZ/AP-Grg1, Tg(ACTB-Bgeo,-Tle1,-ALPP)1Lbe, Tg(CAG-Bgeo,-Tle1,-ALPP)1Lbe
Transgene: Tg(CAG-Bgeo,-Tle1,-ALPP)1Lbe  Location: unknown  
Germline Transmission:  Earliest citation of germline transmission: J:106684
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Transgene Type:    Transgenic (Conditional ready, Inserted expressed sequence, Reporter)
Mutation:    Insertion
Tg(CAG-Bgeo,-Tle1,-ALPP)1Lbe expresses 1 gene
Mutation detailsThe transgene contains a strong cytomegalovirus (CMV) enhancer followed by the chicken beta-actin promoter; a loxP-flanked beta-galactosidase/neomycin resistance fusion (Bgeo) gene with three polyadenylation signals; the coding sequence of the mouse transducin-like enhancer of split 1, homolog of Drosophila E(spl) (Tle1) gene; and the human alkaline phosphatase, placental (Regan isozyme) (ALPP) gene preceded by an interal ribosome entry site (IRES). In mice doubly transgenic for this and a selected Cre recombinase (cre) transgene, excision of the floxed Bgeo results in whole-animal or tissue-specific co-expression of Tle1 and the ALPP reporter gene. (J:106684)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:106684 Allen T, et al., Grg1 acts as a lung-specific oncogene in a transgenic mouse model. Cancer Res. 2006 Feb 1;66(3):1294-301
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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