Mcm4^chaos3
Chemically induced Allele Detail

Summary

• Symbol: Mcm4^chaos3
• Name: minichromosome maintenance complex component 4; chromosomal aberration occurring spontaneously 3
• MGI ID: MGI:3696791
• Synonyms: Chaos3, Mcm4^F345I
• Gene: Mcm4 Location: Chr16:15441761-15455264 bp, - strand Genetic Position: Chr16, 10.09 cM, cytoband B1
• Alliance: Mcm4^chaos3 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: In an ENU mutagenesis screen, a de novo T->A transversion at nucleotide 1033 of the coding region occurred, creating a phenylalanine to isoleucine change at residue 345. (J:117494)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mcm4^chaos3

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mcm4 Mutation: 42 strains or lines available

References

• Original: J:117494 Shima N, et al., A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice. Nat Genet. 2007 Jan;39(1):93-8
• All: 13 reference(s)