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Cdh1tm5(Cdh2)Kem
Targeted Allele Detail
Nomenclature
Symbol: Cdh1tm5(Cdh2)Kem
Name: cadherin 1; targeted mutation 5, Rolf Kemler
MGI ID: MGI:3696713
Synonyms: EcadNcad-GFP
Gene: Cdh1  Location: Chr8:107329983-107396878 bp, + strand  Genetic Position: Chr8, 53.18 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:117056
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsSequence encoding a modified cDNA coding for a C-terminally GFP-tagged cadherin 2 gene was inserted into the ATG start codon, followed by a floxed neo. The neo was subsequently removed via cre-mediated recombination. (J:117056)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdh1 Mutation:  166 strains or lines available
References
Original:  J:117056 Kan NG, et al., Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm. Development. 2007 Jan;134(1):31-41
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory