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Transgene Detail
Symbol: Tg(APOE-ABCA1)30Ssf
Name: transgene insertion 30, Silvia Santamarina-Fojo
MGI ID: MGI:3696684
Synonyms: ABCA1-Tg, hABCA1-A, hABCA1-Tg, hABCA1-tg 30c
Transgene: Tg(APOE-ABCA1)30Ssf  Location: unknown  
Strain of Origin:  C57BL/6N
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(APOE-ABCA1)30Ssf expresses 1 gene
Mutation detailsThe transgene consists of the human apoE promoter, the human ABCA1 cDNA, the poly(A) signal from the human apoE gene, and the hepatic and macrophage control regions of the apoE/apoC-I locus. Northern blot hybridization analysis and densitometric scanning demonstrated a four-fold increase in encoded mRNA in the liver and a three-fold increase in macrophages. The expressed protein was identified in both mouse liver and macrophage cell extracts by western blotting. (J:70494)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:70494 Vaisman BL, et al., ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice. J Clin Invest. 2001 Jul;108(2):303-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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