Clec7a^tm1Yiw
Targeted Allele Detail

Summary

• Symbol: Clec7a^tm1Yiw
• Name: C-type lectin domain family 7, member a; targeted mutation 1, Yoichiro Iwakura
• MGI ID: MGI:3695711
• Synonyms: Dectin1^-, Destin1-KO
• Gene: Clec7a Location: Chr6:129438554-129449742 bp, - strand Genetic Position: Chr6, 63.34 cM, cytoband F3
• Alliance: Clec7a^tm1Yiw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116670
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a neomycin resistance gene. Absence of transcript was confirmed in Northern blot. (J:116670)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Clec7a Mutation: 22 strains or lines available

References

• Original: J:116670 Saijo S, et al., Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans. Nat Immunol. 2007 Jan;8(1):39-46
• All: 36 reference(s)