Abcg1^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Abcg1^tm1Dgen
• Name: ATP binding cassette subfamily G member 1; targeted mutation 1, Deltagen
• MGI ID: MGI:3695417
• Synonyms: Abcg1^-
• Gene: Abcg1 Location: Chr17:31276668-31336958 bp, + strand Genetic Position: Chr17, 15.8 cM, cytoband A2-B
• Alliance: Abcg1^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117028
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was used to replace 21 bp, encoding seven amino acids (GPSGAGK), in exon 3 with a floxed IRES-lacZ-neo-pA cassette. (J:117028)

Expression

In Mice Carrying this Mutation:	71 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abcg1 Mutation: 45 strains or lines available

Notes

When used in bone marrow transplant into Ldlr^tm1Her homozygous mice, Abca1^tm1Jdm Abcg1^tm1Dgen homozygous cells accelerate the development of atherosclerosis. (J:130777)

References

• Original: J:117028 Kennedy MA, et al., ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation. Cell Metab. 2005 Feb;1(2):121-31
• All: 56 reference(s)