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Abcg1tm1Dgen
Targeted Allele Detail
Nomenclature
Symbol: Abcg1tm1Dgen
Name: ATP-binding cassette, sub-family G (WHITE), member 1; targeted mutation 1, Deltagen
MGI ID: MGI:3695417
Synonyms: Abcg1-
Gene: Abcg1  Location: Chr17:31057698-31115777 bp, + strand  Genetic Position: Chr17, 15.8 cM, cytoband A2-B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:117028
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Deltagen
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was used to replace 21 bp, encoding seven amino acids (GPSGAGK), in exon 3 with a floxed IRES-lacZ-neo-pA cassette. (J:117028)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abcg1 Mutation:  14 strains or lines available
Notes
When used in bone marrow transplant into Ldlrtm1Her homozygous mice, Abca1tm1Jdm Abcg1tm1Dgen homozygous cells accelerate the development of atherosclerosis. (J:130777)

References
Original:  J:117028 Kennedy MA, et al., ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation. Cell Metab. 2005 Feb;1(2):121-31
All:  47 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory