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Tg(Slc5a2-cre)1Tauc
Transgene Detail
Summary
Symbol: Tg(Slc5a2-cre)1Tauc
Name: transgene insertion 1, Michel Tauc
MGI ID: MGI:3694735
Synonyms: iL1-sglt2-Cre, mSglt2 5pr-mut-Cre
Transgene: Tg(Slc5a2-cre)1Tauc  Location: unknown  
Alliance: Tg(Slc5a2-cre)1Tauc page
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Slc5a2-cre)1Tauc expression driven by 1 gene
 
Mutation detailsThe transgene expresses Cre recombinase under control of the promoter region of the gene encoding solute carrier family 5 (sodium/glucose cotransporter), member 2, including 1952 bp of 5'-flanking sequence, the first exon (containing a mutated translation initiation codon), first intron and 23 bp of the second exon. X-gal staining of multiple tissues from mice doubly transgenic for this transgene and for the E. coli beta-galactosidase gene (lacZ) preceded by a loxP-flanked stop sequence (knocked into the Gt(ROSA)26Sor locus) demonstrated beta-galactosidase activity only in the kidney. Immunohistochemical analysis of X-gal-stained kidney cryostat sections for markers specific to different regions of the nephron showed colocalization of X-gal staining only with anti-megalin antibody, which identifies the proximal tubules. (J:111666)
Recombinase
activity
Activity:
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Driver: Slc5a2 (species not specified)
Summary of all recombinase alleles driven by Slc5a2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:111666 Rubera I, et al., Specific Cre/Lox recombination in the mouse proximal tubule. J Am Soc Nephrol. 2004 Aug;15(8):2050-6
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory