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Targeted Allele Detail
Symbol: Plagl1tm1Jour
Name: pleiomorphic adenoma gene-like 1; targeted mutation 1, Laurent Journot
MGI ID: MGI:3693683
Synonyms: Zac1-
Gene: Plagl1  Location: Chr10:13060504-13131694 bp, + strand  Genetic Position: Chr10, 4.72 cM
Germline Transmission:  Earliest citation of germline transmission: J:116147
Parent Cell Line:  H1 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was desgned to replace sequence including the ATG and the entire zinc finger domain with a neomycin resistance cassette. Absence of protein in mutant pituitary glands was confirmed by Western blot analysis. (J:116147)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 11 assay results
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plagl1 Mutation:  19 strains or lines available
Original:  J:116147 Varrault A, et al., Zac1 regulates an imprinted gene network critically involved in the control of embryonic growth. Dev Cell. 2006 Nov;11(5):711-22
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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