Cdh1^tm1Jjon
Targeted Allele Detail

Summary

• Symbol: Cdh1^tm1Jjon
• Name: cadherin 1; targeted mutation 1, Jos Jonkers
• MGI ID: MGI:3693661
• Synonyms: Cdh1^f, EcadF
• Gene: Cdh1 Location: Chr8:107329983-107396878 bp, + strand Genetic Position: Chr8, 53.18 cM, cytoband D
• Alliance: Cdh1^tm1Jjon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116152
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exons 4 through 15 were flanked with loxP sites (J:116152)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Cdh1^tm1Jjon

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdh1 Mutation: 171 strains or lines available

References

• Original: J:116152 Derksen PW, et al., Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis. Cancer Cell. 2006 Nov;10(5):437-49
• All: 21 reference(s)