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Hdac7tm1Eno
Targeted Allele Detail
Nomenclature
Symbol: Hdac7tm1Eno
Name: histone deacetylase 7; targeted mutation 1, Eric N Olson
MGI ID: MGI:3693627
Synonyms: Hdac7-
Gene: Hdac7  Location: Chr15:97792664-97844502 bp, - strand  Genetic Position: Chr15, 53.79 cM, cytoband F2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:116008
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2-5, including the MEF2 binding domain, were replaced with a promoter-less lacz-neo cassette in frame with exon 2. RT-PCR confirmed absence of transcript from mutant mice. (J:116008)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hdac7 Mutation:  4 strains or lines available
References
Original:  J:116008 Chang S, et al., Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10. Cell. 2006 Jul 28;126(2):321-34
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory