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Smad4tm1Rdp
Targeted Allele Detail
Nomenclature
Symbol: Smad4tm1Rdp
Name: SMAD family member 4; targeted mutation 1, Ronald DePinho
MGI ID: MGI:3693621
Synonyms: Smad4L
Gene: Smad4  Location: Chr18:73639009-73703780 bp, - strand  Genetic Position: Chr18, 49.51 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:116130
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    LoxP sites were inserted to flank exons 8 and 9. (J:116130)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad4 Mutation:  12 strains or lines available
References
Original:  J:116130 Bardeesy N, et al., Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes Dev. 2006 Nov 15;20(22):3130-46
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory