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Crtaptm1Brle
Targeted Allele Detail
Nomenclature
Symbol: Crtaptm1Brle
Name: cartilage associated protein; targeted mutation 1, Brendan Lee
MGI ID: MGI:3693334
Synonyms: Crtap-
Gene: Crtap  Location: Chr9:114375134-114390675 bp, - strand  Genetic Position: Chr9, 64.39 cM, cytoband F3-F4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:116096
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced part of exon 1 and all of exon 2. Absence of transcript was confirmed by Northern blot and RT-PCR analyses. (J:116096)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crtap Mutation:  4 strains or lines available
References
Original:  J:116096 Morello R, et al., CRTAP is required for prolyl 3- hydroxylation and mutations cause recessive osteogenesis imperfecta. Cell. 2006 Oct 20;127(2):291-304
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory