Ret^tm3Cos
Targeted Allele Detail

Summary

• Symbol: Ret^tm3Cos
• Name: ret proto-oncogene; targeted mutation 3, Frank Costantini
• MGI ID: MGI:3693325
• Synonyms: c-Ret-KI^S697A, Ret^tm2Mat
• Gene: Ret Location: Chr6:118128706-118174679 bp, - strand Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
• Alliance: Ret^tm3Cos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116089
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A targeting vector was designed to insert the S697A mutation into exon 11. A neo cassette included in the vector was removed by crossing with mice expressing cre recombinase in the germline. (J:116089)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ret Mutation: 53 strains or lines available

References

• Original: J:116089 Asai N, et al., Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells. Development. 2006 Nov;133(22):4507-16
• All: 4 reference(s)