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Cdc42tm1Yizh
Targeted Allele Detail
Nomenclature
Symbol: Cdc42tm1Yizh
Name: cell division cycle 42; targeted mutation 1, Yi Zheng
MGI ID: MGI:3693320
Synonyms: cdc42flox, Cdc42loxP
Gene: Cdc42  Location: Chr4:137047007-137085031 bp, - strand  Genetic Position: Chr4, 69.83 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:116100
Parent Cell Line:  iTL1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe targeting construct introduced a neomycin resistance cassette (neor), flanked on each side by a loxP followed by a frt site, upstream of exon 2 and a single loxP site downstream of exon 2. The neor was deleted by FLP recombinase, leaving a single frt site in intron 1 and loxP sites flanking exon 2, which contains the translation initiation site. (J:120090)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 32 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdc42 Mutation:  42 strains or lines available
References
Original:  J:116100 Chen L, et al., Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16520-5
All:  37 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory