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Tg(Myh6-Tnnt2*R92W)1Jcf
Transgene Detail
Nomenclature
Symbol: Tg(Myh6-Tnnt2*R92W)1Jcf
Name: transgene insertion 1, Jil C Tardiff
MGI ID: MGI:3693250
Synonyms: R92W
Transgene: Tg(Myh6-Tnnt2*R92W)1Jcf  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-Tnnt2*R92W)1Jcf expresses 1 gene
 
Mutation detailsThis transgene expresses a mouse Tnnt2 gene, with codon 92 mutated to encode a tryptophan instead of the arginine and an 11-amino acid c-myc epitope added to the 5' end of the coding region, under the control of a rat alpha-myosin heavy chain promoter. This line expresses 50% of the total Tnnt2 as the mutant transgenic form. (J:104369)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:104369 Ertz-Berger BR, et al., Changes in the chemical and dynamic properties of cardiac troponin T cause discrete cardiomyopathies in transgenic mice. Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18219-24
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/04/2019
MGI 6.14
The Jackson Laboratory