Ercc1^tm2Dwm
Targeted Allele Detail

Summary

• Symbol: Ercc1^tm2Dwm
• Name: excision repair cross-complementing rodent repair deficiency, complementation group 1; targeted mutation 2, David W Melton
• MGI ID: MGI:3692923
• Synonyms: Ercc1^flox
• Gene: Ercc1 Location: Chr7:19079016-19090449 bp, + strand Genetic Position: Chr7, 9.6 cM
• Alliance: Ercc1^tm2Dwm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115849
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: In the first step of a two step process, exons 3-5 were replaced with an Hprt minigene. In the second step, the Hprt1 marker was replaced with the Ercc1 exons 3-5 region flanked by loxP sites. (J:115849)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ercc1 Mutation: 27 strains or lines available

References

• Original: J:115849 Doig J, et al., Mice with skin-specific DNA repair gene (Ercc1) inactivation are hypersensitive to ultraviolet irradiation-induced skin cancer and show more rapid actinic progression. Oncogene. 2006 Oct 12;25(47):6229-38
• All: 13 reference(s)