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Elovl4tm1Rayy
Targeted Allele Detail
Nomenclature
Symbol: Elovl4tm1Rayy
Name: elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4; targeted mutation 1, Radha Ayyagari
MGI ID: MGI:3692750
Synonyms: Elovl4del, E_mut-
Gene: Elovl4  Location: Chr9:83778692-83806277 bp, - strand  Genetic Position: Chr9, 45.6 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:114752
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutation:    Intragenic deletion
 
Mutation detailsA 5 bp deletion was engineered in exon 6. A floxed neo was included in the cassette and subsequently removed via cre expression. Western blot confirmed the presence of mutant protein. (J:114752)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Elovl4 Mutation:  17 strains or lines available
References
Original:  J:114752 Vasireddy V, et al., Elovl4 5-bp-deletion knock-in mice develop progressive photoreceptor degeneration. Invest Ophthalmol Vis Sci. 2006 Oct;47(10):4558-68
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory