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Tg(Myh6-Tnnt2)117Lnwd
Transgene Detail
Nomenclature
Symbol: Tg(Myh6-Tnnt2)117Lnwd
Name: transgene insertion 117, Leslie A Leinwand
MGI ID: MGI:3692598
Synonyms: cTnT(trunc)
Transgene: Tg(Myh6-Tnnt2)117Lnwd  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-Tnnt2)117Lnwd expresses 1 gene
 
Mutation detailsThis transgene expresses a carboxy-terminal truncated mouse Tnnt2 gene under the control of a rat alpha-myosin heavy chain promoter. The truncation corresponds to a truncation described in familial hypertrophic cardiomyopathy patients in which exons 15 and 16 are missing. This line expresses less than 5% of total Tnnt2 as the mutant transgenic form. (J:48301)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:48301 Tardiff JC, et al., A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy. J Clin Invest. 1998 Jun 15;101(12):2800-11
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/11/2018
MGI 6.12
The Jackson Laboratory