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Tg(Myh6-Tnnt2*R92Q)2Lnwd
Transgene Detail
Nomenclature
Symbol: Tg(Myh6-Tnnt2*R92Q)2Lnwd
Name: transgene insertion 2, Leslie A Leinwand
MGI ID: MGI:3692450
Synonyms: 67%, R92Q, R92Q-Myc
Transgene: Tg(Myh6-Tnnt2*R92Q)2Lnwd  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-Tnnt2*R92Q)2Lnwd expresses 1 gene
 
Mutation detailsThis transgene expresses a mouse Tnnt2 gene, with codon 92 mutated to encode an glutamine instead of the arginine and an 11-amino acid c-myc epitope added to the 5' end of the coding region, under the control of a rat alpha-myosin heavy chain promoter. This line expresses 67% of the total Tnnt2 as the mutant transgenic form. (J:56911)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:56911 Tardiff JC, et al., Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathy. J Clin Invest. 1999 Aug;104(4):469-81
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory