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Dgkdtm1Mtop
Targeted Allele Detail
Summary
Symbol: Dgkdtm1Mtop
Name: diacylglycerol kinase, delta; targeted mutation 1, Matthew K Topham
MGI ID: MGI:3692387
Synonyms: Dgkd-
Gene: Dgkd  Location: Chr1:87781009-87872902 bp, + strand  Genetic Position: Chr1, 44.44 cM
Alliance: Dgkdtm1Mtop page
Morphology of Dgkdtm1Mtop/Dgkdtm1Mtop mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:115297
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 6-8 were replaced with a neomycin resistance gene. These exons encode the second zinc finger motif and part of the catalytic domain. Immunoblot and RT-PCR confirmed absence of expression in mutants. (J:115297)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 20 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dgkd Mutation:  39 strains or lines available
References
Original:  J:115297 Crotty T, et al., Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15485-90
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory