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Targeted Allele Detail
Symbol: Tdrd1tm1Chum
Name: tudor domain containing 1; targeted mutation 1, Shinichiro Chuma
MGI ID: MGI:3691852
Synonyms: Tdrd1tm1
Gene: Tdrd1  Location: Chr19:56826209-56870012 bp, + strand  Genetic Position: Chr19, 52.0 cM
Germline Transmission:  Earliest citation of germline transmission: J:115333
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to disrupt the first ATG of transcript variants 1-3 and replace the promoter of variant 4 by the insertion of a neo in the ATG in exon 3. In testes, a truncated Tdrd1 mRNA was detected, but Western blot analysis showed absence of any Tdrd1 protein. (J:115333)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tdrd1 Mutation:  30 strains or lines available
Original:  J:115333 Chuma S, et al., Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell differentiation and nuage/germinal granule formation in mice. Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15894-9
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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