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Targeted Allele Detail
Symbol: Pik3catm1Jjz
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; targeted mutation 1, Jean J Zhao
MGI ID: MGI:3691486
Synonyms: p110alphaflox, p110alpha flox
Gene: Pik3ca  Location: Chr3:32451203-32520256 bp, + strand  Genetic Position: Chr3, 15.7 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:115274
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsExon 1 was flanked by lox P sites, with an FRT-flanked selection cassette between exon 1 and the downstream loxP site. The selection cassette was subsequently removed from the locus via transient transfection with a FLP recombinase plasmid. (J:115274)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pik3ca Mutation:  49 strains or lines available
Original:  J:115274 Zhao JJ, et al., The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16296-300
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory