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Cd151tm1Nki
Targeted Allele Detail
Nomenclature
Symbol: Cd151tm1Nki
Name: CD151 antigen; targeted mutation 1, The Netherlands Cancer Institute
MGI ID: MGI:3691076
Synonyms: Cd151-, Cd151tm1Son
Gene: Cd151  Location: Chr7:141467362-141471479 bp, + strand  Genetic Position: Chr7, 86.82 cM
Glomerular basement membrane abnormalities and foot process effacement in kidneys of mildly affected Cd151tm1Nki/Cd151tm1Nki and Itga3tm1Son/Itga3tm1Son Tg(NPHS2-cre)295Lbh/0 mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:114988
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loP site was inserted upstream of exon 2. An FRT-flanked puromycin resistance cassette with a 3' loxP site was inserted downstream of exon 4. Exons 2-4 were removed via cre-mediated recombination. Immunoblot failed to detect protein in mutant MEFs. The final allele lacks the puromycin resistance cassette. The floxed allele Cd151tm2Nki was used to generate this allele. (J:114988)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd151 Mutation:  19 strains or lines available
References
Original:  J:114988 Sachs N, et al., Kidney failure in mice lacking the tetraspanin CD151. J Cell Biol. 2006 Oct 9;175(1):33-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory