Kmt2a^tm1Clgr
Targeted Allele Detail

Summary

• Symbol: Kmt2a^tm1Clgr
• Name: lysine (K)-specific methyltransferase 2A; targeted mutation 1, Michael A Caligiuri
• MGI ID: MGI:3691062
• Synonyms: Mll^PTD
• Gene: Kmt2a Location: Chr9:44714652-44792594 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Kmt2a^tm1Clgr page

Vertebral transformation is seen in Kmt2a^tm1Clgr/Mll1⁺ mice at 20 weeks of age

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115001
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Exons 5-11 were targeted to intron 4 of the locus. RT-PCR and sequencing detected a correctly spliced, in-frame fusion transcript confirming the correct targeting of the vector. (J:115001)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt2a Mutation: 135 strains or lines available

References

• Original: J:115001 Dorrance AM, et al., Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations. J Clin Invest. 2006 Oct;116(10):2707-16
• All: 14 reference(s)