About   Help   FAQ
Targeted Allele Detail
Symbol: Adgrl1tm1Sud
Name: adhesion G protein-coupled receptor L1; targeted mutation 1, Thomas C Sudhof
MGI ID: MGI:3691022
Gene: Adgrl1  Location: Chr8:83900105-83941954 bp, + strand  Genetic Position: Chr8, 40.22 cM
Germline Transmission:  Earliest citation of germline transmission: J:115214
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2, which encodes amino acids 24-95, and some flanking intronic DNA have been replaced by a neomycin resistance cassette, generating a translational reading-frame shift. Immunoblot analysis with antibodies against the N-terminal, extracellular part of the protein demonstrated its absence in synoptosomes of homozygous mutant mice. (J:115214)
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adgrl1 Mutation:  22 strains or lines available
Original:  J:115214 Tobaben S, et al., Genetic analysis of alpha-latrotoxin receptors reveals functional interdependence of CIRL/latrophilin 1 and neurexin 1 alpha. J Biol Chem. 2002 Feb 22;277(8):6359-65
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.03
The Jackson Laboratory