Il21^tm1Llit
Targeted Allele Detail

Summary

• Symbol: Il21^tm1Llit
• Name: interleukin 21; targeted mutation 1, L Li
• MGI ID: MGI:3690462
• Gene: Il21 Location: Chr3:37276908-37286785 bp, - strand Genetic Position: Chr3, 18.36 cM, cytoband B
• Alliance: Il21^tm1Llit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114783
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 1 and 2 were replaced with an IRES-LacZ/Mc1 neo cassette. (J:114783)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il21 Mutation: 40 strains or lines available

References

• Original: J:114783 Shang XZ, et al., IgE isotype switch and IgE production are enhanced in IL-21-deficient but not IFN-gamma-deficient mice in a Th2-biased response. Cell Immunol. 2006 Jun;241(2):66-74
• All: 1 reference(s)