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Fkbp4tm1Shou
Targeted Allele Detail
Nomenclature
Symbol: Fkbp4tm1Shou
Name: FK506 binding protein 4; targeted mutation 1, Weinian Shou
MGI ID: MGI:3690438
Synonyms: Fkbp52-
Gene: Fkbp4  Location: Chr6:128429735-128438677 bp, - strand  Genetic Position: Chr6, 63.0 cM
Abnormal male reproductive anatomy in Fkbp4tm1Shou/Fkbp4tm1Shou mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:114715
Parent Cell Line:  CCE916 (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2-5 were replaced with a PGK-neo cassette. Northern and Western blot confirmed that the expression was absent in mutant mice. (J:114715)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fkbp4 Mutation:  26 strains or lines available
References
Original:  J:114715 Yang Z, et al., FK506-binding protein 52 is essential to uterine reproductive physiology controlled by the progesterone receptor a isoform. Mol Endocrinol. 2006 Nov;20(11):2682-94
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory