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Tg(tetO-EGFR*L858R)57Hev
Transgene Detail
Nomenclature
Symbol: Tg(tetO-EGFR*L858R)57Hev
Name: transgene insertion 57, Harold E Varmus
MGI ID: MGI:3690075
Synonyms: EGFRL858R, L858R57, TetO-EGFRL858R
Transgene: Tg(tetO-EGFR*L858R)57Hev  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F2
Transgene
description
Transgene Type:    Transgenic (Inducible, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsA mutant human epidermal growth factor receptor (EGFR) cDNA with a T-to-G nucleotide substitution in exon 21 that replaces leucine with arginine at amino acid position 858 (L858R) was cloned between a tetracycline-responsive element and an intron and polyadenylation signal from the mouse protamine 1 gene. Mice with this transgene that express the tetracycline transactivator (tTA) or reverse transactivator (rtTA) protein under control of a tissue- specific promoter can be induced to express the mutant EGFR in tissues or cell types of interest by administration/withdrawal of doxycycline. Transgene expression in this line is correlated with a head-to-tail array of transgenes and not with other, independently segregating transgene copies. (J:109092)
Phenotypes
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Line 56 was also generated.

References
Original:  J:109092 Politi K, et al., Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors. Genes Dev. 2006 Jun 1;20(11):1496-510
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory