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Targeted Allele Detail
Symbol: Akt2tm1Hem
Name: thymoma viral proto-oncogene 2; targeted mutation 1, Brian A Hemmings
MGI ID: MGI:3690020
Synonyms: Akt2-, PKBbeta-
Gene: Akt2  Location: Chr7:27591552-27640826 bp, + strand  Genetic Position: Chr7, 15.94 cM, cytoband B1
Germline Transmission:  Earliest citation of germline transmission: J:114675
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe insertion of a neomycin resistance cassette resulted in the partial deletion of exon 4 and a frame shift in the ORF of the gene. Protein was not detected by isoform-specific antisera in mutants. (J:114675)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Akt2 Mutation:  43 strains or lines available
Original:  J:114675 Dummler B, et al., Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies. Mol Cell Biol. 2006 Nov;26(21):8042-51
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory