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Akt2tm1Hem
Targeted Allele Detail
Nomenclature
Symbol: Akt2tm1Hem
Name: thymoma viral proto-oncogene 2; targeted mutation 1, Brian A Hemmings
MGI ID: MGI:3690020
Synonyms: Akt2-, PKBbeta-
Gene: Akt2  Location: Chr7:27591557-27639453 bp, + strand  Genetic Position: Chr7, 15.94 cM, cytoband B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:114675
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe insertion of a neomycin resistance cassette resulted in the partial deletion of exon 4 and a frame shift in the ORF of the gene. Protein was not detected by isoform-specific antisera in mutants. (J:114675)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Akt2 Mutation:  25 strains or lines available
References
Original:  J:114675 Dummler B, et al., Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies. Mol Cell Biol. 2006 Nov;26(21):8042-51
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/09/2019
MGI 6.14
The Jackson Laboratory