About   Help   FAQ
Tg(Myh6-TNNI3*G203S)4Chs
Transgene Detail
Nomenclature
Symbol: Tg(Myh6-TNNI3*G203S)4Chs
Name: transgene insertion 4, Christopher Semsarian
MGI ID: MGI:3690014
Synonyms: cTnI-G203S
Transgene: Tg(Myh6-TNNI3*G203S)4Chs  Location: unknown  
Transgene
origin
Strain of Origin:  Not Applicable
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-TNNI3*G203S)4Chs expresses 1 gene
 
Mutation detailsThis transgene consists of human TNNI3, with an amino acid substitution of a glycine by serine at codon 203 that causes familial hypertrophic cardiomyopathy in humans, under the control of the cardiac specific alpha-myosin heavy chain promoter. This line expresses the lowest amount of mutant protein and represents relative proportions of mutant protein of 48%. (J:114537)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:114537 Tsoutsman T, et al., Molecular insights from a novel cardiac troponin I mouse model of familial hypertrophic cardiomyopathy. J Mol Cell Cardiol. 2006 Oct;41(4):623-32
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/18/2020
MGI 6.14
The Jackson Laboratory