Tg(Myh6-TNNI3*G203S)1Chs
Transgene Detail
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Symbol: |
Tg(Myh6-TNNI3*G203S)1Chs |
Name: |
transgene insertion 1, Christopher Semsarian |
MGI ID: |
MGI:3690009 |
Synonyms: |
cTnI-G203S |
Transgene: |
Tg(Myh6-TNNI3*G203S)1Chs Location: unknown
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Alliance: |
Tg(Myh6-TNNI3*G203S)1Chs page
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Strain of Origin: |
Not Applicable
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Myh6-TNNI3*G203S)1Chs expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
TNNI3 (7137) |
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Transgene codes for a protein with a glycine to serine mutation. |
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Mutation details: This transgene consists of human TNNI3, with an amino acid substitution of a glycine by serine at codon 203 that causes familial hypertrophic cardiomyopathy in humans, under the control of the cardiac specific alpha-myosin heavy chain promoter. This line expresses the highest amount of mutant protein and represents relative proportions of mutant protein of 83%.
(J:114537)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:114537 Tsoutsman T, et al., Molecular insights from a novel cardiac troponin I mouse model of familial hypertrophic cardiomyopathy. J Mol Cell Cardiol. 2006 Oct;41(4):623-32 |
All: |
10 reference(s) |
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