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Il4ratm2Fbb
Targeted Allele Detail
Nomenclature
Symbol: Il4ratm2Fbb
Name: interleukin 4 receptor, alpha; targeted mutation 2, Frank Brombacher
MGI ID: MGI:3689995
Synonyms: IL-4Ralphaflox
Gene: Il4ra  Location: Chr7:125552271-125579474 bp, + strand  Genetic Position: Chr7, 68.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:114751
Parent Cell Line:  BALB/c-I (ES Cell)
Strain of Origin:  BALB/cJ
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA neo-tk was flanked by loxP sites and inserted into intron 9 and an additional loxP site in intron 6. The neo was removed via transient cre expression, leaving exons 7-9 floxed. (J:114751)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il4ra Mutation:  26 strains or lines available
References
Original:  J:114751 Herbert DR, et al., Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. Immunity. 2004 May;20(5):623-35
All:  40 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory