About   Help   FAQ
Mogtm1(cre)Gkl
Targeted Allele Detail
Nomenclature
Symbol: Mogtm1(cre)Gkl
Name: myelin oligodendrocyte glycoprotein; targeted mutation 1, George Kollias
MGI ID: MGI:3689957
Synonyms: MOGi-cre
Gene: Mog  Location: Chr17:37010743-37023398 bp, - strand  Genetic Position: Chr17, 19.16 cM, cytoband C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:114741
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe open reading frame of the Cre recombinase gene, followed by the human growth hormone polyadenylation signal and the neomycin resistance gene, has replaced all except the 5'-most segment of the first exon, the first intron and all but the 3'-most part of the second exon of the myelin oligodendrocyte glycoprotein gene, thus targeting Cre expression to oligodendrocytes (ODCs). Western blot analysis demonstrated that wild-type MOG protein is present in heterozygous and wild-type brains at comparable levels, but is not detectable in homozygous mutant brain. (J:114741)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Mog     Summary of all recombinase alleles driven by Mog.
 

Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mog Mutation:  38 strains or lines available
References
Original:  J:114741 Hovelmeyer N, et al., Apoptosis of oligodendrocytes via Fas and TNF-R1 is a key event in the induction of experimental autoimmune encephalomyelitis. J Immunol. 2005 Nov 1;175(9):5875-84
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/25/2015
MGI 5.21
The Jackson Laboratory