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Abcc3tm1Kruh
Targeted Allele Detail
Nomenclature
Symbol: Abcc3tm1Kruh
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 3; targeted mutation 1, Gary D Kruh
MGI ID: MGI:3689906
Synonyms: Mrp3-
Gene: Abcc3  Location: Chr11:94343298-94392997 bp, - strand  Genetic Position: Chr11, 58.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:114229
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 6-8, including nucleotides 613-996, were replaced by a neo cassette. The substitution resulted in a frame shift. Western blot failed to detect wild-type protein in mutant mice. (J:114229)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abcc3 Mutation:  32 strains or lines available
References
Original:  J:114229 Belinsky MG, et al., Analysis of the in vivo functions of Mrp3. Mol Pharmacol. 2005 Jul;68(1):160-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/10/2018
MGI 6.12
The Jackson Laboratory