About   Help   FAQ
Targeted Allele Detail
Symbol: Six1tm2Kwk
Name: sine oculis-related homeobox 1; targeted mutation 2, Kiyoshi Kawakami
MGI ID: MGI:3689891
Synonyms: Six1-/-Six4-/-
Gene: Six1  Location: Chr12:73040015-73053887 bp, - strand  Genetic Position: Chr12, 30.34 cM
Germline Transmission:  Earliest citation of germline transmission: J:114468
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThis allele was created in ES cells carrying the Six4tm1Kwk mutation in which the region of exon 1 encoding the Six homologous region and homeobox was replaced with an in-frame lacZ-neo cassette. The targeting event resulted in the entire sine oculis-related homeobox 1 homolog being replaced with an EGFP and a hygromicn-B-phosphotransferase gene. (J:114468)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 22 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Six1 Mutation:  10 strains or lines available
Original:  J:114468 Konishi Y, et al., Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis. Brain Res. 2006 Oct 20;1116(1):93-102
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.12
The Jackson Laboratory