Six1^tm2Kwk
Targeted Allele Detail

Summary

• Symbol: Six1^tm2Kwk
• Name: sine oculis-related homeobox 1; targeted mutation 2, Kiyoshi Kawakami
• MGI ID: MGI:3689891
• Synonyms: Six1^-(gfp), Six1^-/-Six4^-/-
• Gene: Six1 Location: Chr12:73088601-73093486 bp, - strand Genetic Position: Chr12, 30.34 cM
• Alliance: Six1^tm2Kwk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114468
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele was created in ES cells carrying the Six4^tm1Kwk mutation in which the region of exon 1 encoding the Six homologous region and homeobox was replaced with an in-frame lacZ-neo cassette. The targeting event resulted in the entire sine oculis-related homeobox 1 homolog being replaced with an EGFP and a hygromicn-B-phosphotransferase gene. (J:114468)

Expression

In Mice Carrying this Mutation:	22 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Six1 Mutation: 18 strains or lines available

References

• Original: J:114468 Konishi Y, et al., Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis. Brain Res. 2006 Oct 20;1116(1):93-102
• All: 6 reference(s)