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Ightm2Rsky
Targeted Allele Detail
Nomenclature
Symbol: Ightm2Rsky
Name: immunoglobulin heavy chain complex; targeted mutation 2, Klaus Rajewsky
MGI ID: MGI:3689719
Synonyms: 3-83Hi, 3-83mCkappa, Ightm1Pld
Gene: Igh  Location: unknown  Genetic Position: Chr12, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:111431
Parent Cell Line:  E14.1TG3B1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsThe rearranged 3-83 heavy chain was inserted into the IgHa locus via homologous recombination. A floxed neo selection cassette was also introduced and subsequently removed by Cre mediated recombination. (J:111431)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Igh Mutation:  44 strains or lines available
References
Original:  J:111431 Pelanda R, et al., Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification. Immunity. 1997 Dec;7(6):765-75
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory