Igh^tm2Rsky
Targeted Allele Detail

Summary

• Symbol: Igh^tm2Rsky
• Name: immunoglobulin heavy chain complex; targeted mutation 2, Klaus Rajewsky
• MGI ID: MGI:3689719
• Synonyms: 3-83Hi, 3-83mCkappa, Igh^tm1Pld
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111431
• Parent Cell Line: E14.1TG3B1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The rearranged 3-83 heavy chain was inserted into the IgH^a locus via homologous recombination. A floxed neo selection cassette was also introduced and subsequently removed by Cre mediated recombination. (J:111431)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 43 strains or lines available

References

• Original: J:111431 Pelanda R, et al., Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification. Immunity. 1997 Dec;7(6):765-75
• All: 15 reference(s)