Gt(ROSA)26Sor^tm1Fia
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1Fia
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Fraz A Ismat
• MGI ID: MGI:3689410
• Synonyms: HA-GRD^k
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1Fia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114455
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A vector containing a HA-tagged segment of human neurofibromatosis 1 cDNA encoding the 216 amino acid GTPase-activating protein-related domain was inserted into the locus with a floxed PGK-neo. The presence of the neo blocked expression of the mutant protein. (J:114455)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

References

• Original: J:114455 Ismat FA, et al., The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice. J Clin Invest. 2006 Sep;116(9):2378-84
• All: 4 reference(s)