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Gt(ROSA)26Sortm1Fia
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1Fia
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Fraz A Ismat
MGI ID: MGI:3689410
Synonyms: HA-GRDk
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077333 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:114455
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsA vector containing a HA-tagged segment of human neurofibromatosis 1 cDNA encoding the 216 amino acid GTPase-activating protein-related domain was inserted into the locus with a floxed PGK-neo. The presence of the neo blocked expression of the mutant protein. (J:114455)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  253 strains or lines available
References
Original:  J:114455 Ismat FA, et al., The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice. J Clin Invest. 2006 Sep;116(9):2378-84
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory