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Tg(Sp7-tTA,tetO-EGFP/cre)1Amc
Transgene Detail
Nomenclature
Symbol: Tg(Sp7-tTA,tetO-EGFP/cre)1Amc
Name: transgene insertion 1, Andrew P McMahon
MGI ID: MGI:3689350
Synonyms: osterix-Cre, Osx1-cre, Osx1-GFP::Cre, Osx-Cre, Osx-Cre::GFP, Osx-gfp, The Sp7-Cre-EGFP
Transgene: Tg(Sp7-tTA,tetO-EGFP/cre)1Amc  Location: unknown  
Transgene
origin
Strain of Origin:  CD-1
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase, Reporter, Transactivator)
Inducer:    induced by doxycycline
Mutation:    Insertion
 
Mutation detailsA tTA-regulated GFP::Cre construct, which has the tetracycline-regulated transactivator (tTA) cassette upstream of a tetracycline-responsive element (tetO)-controlled Enhanced Green Fluorescent Protein/cre fusion protein was used to modifiy a bacterial artificial chromosome (BAC) encoding exon 1 of the mouse Sp7 gene (formerly osterix or Osx1). A frt-flanked selection cassette following the tTA-regulated GFP::Cre was removed from correctly targeted bacteria via transient flpe expression. A 5.2 kb portion of the modified BAC (Osx1-GFP::Cre) was used for pronuclear injection into fertilized CD1 embryos. (J:114494)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Sp7     Summary of all recombinase alleles driven by Sp7.
 

Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:114494 Rodda SJ, et al., Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development. 2006 Aug;133(16):3231-44
All:  74 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory