About   Help   FAQ
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc
Transgene Detail
Summary
Symbol: Tg(Sp7-tTA,tetO-EGFP/cre)1Amc
Name: transgene insertion 1, Andrew P McMahon
MGI ID: MGI:3689350
Synonyms: osterix-Cre, Osx1-cre, Osx1-GFP::Cre, Osx-Cre, Osx-Cre::GFP, Osx-gfp, The Sp7-Cre-EGFP
Transgene: Tg(Sp7-tTA,tetO-EGFP/cre)1Amc  Location: unknown  
Alliance: Tg(Sp7-tTA,tetO-EGFP/cre)1Amc page
Transgene
origin
Strain of Origin:  CD-1
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase, Reporter, Transactivator)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
 
Mutation detailsA tTA-regulated GFP::Cre construct, which has the tetracycline-regulated transactivator (tTA) cassette upstream of a tetracycline-responsive element (tetO)-controlled Enhanced Green Fluorescent Protein/cre fusion protein was used to modify a bacterial artificial chromosome (BAC) encoding exon 1 of the mouse Sp7 gene (formerly osterix or Osx1). An frt-flanked selection cassette following the tTA-regulated GFP::Cre was removed from correctly targeted bacteria via transient flpe expression. A 5.2 kb portion of the modified BAC (Osx1-GFP::Cre) was used for pronuclear injection into fertilized CD1 embryos. (J:114494)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Sp7 (mouse)
Summary of all recombinase alleles driven by Sp7.
 

Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Mice Carrying this Mutation: 8 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Tg(Sp7-tTA,tetO-EGFP/cre)1Amc
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:114494 Rodda SJ, et al., Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development. 2006 Aug;133(16):3231-44
All:  261 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
11/22/2022
MGI 6.22
The Jackson Laboratory