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Trpc3Mwk
Chemically induced Allele Detail
Nomenclature
Symbol: Trpc3Mwk
Name: transient receptor potential cation channel, subfamily C, member 3; moonwalker
MGI ID: MGI:3689326
Synonyms: Bhv7
Gene: Trpc3  Location: Chr3:36620482-36690167 bp, - strand  Genetic Position: Chr3, 17.93 cM, cytoband B
Mutation
origin
Strain of Origin:  BALB/c
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsThis ENU induced mutation is a point mutation in exon 7: an A-to-G nucleotide change at position 1903. This causes a threonine-to-alanine amino acid change at residue 635 in the highly conserved S4/S5 linker region. (J:148340)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Trpc3 Mutation:  20 strains or lines available
References
Original:  J:148340 Becker EB, et al., A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice. Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6706-11
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory