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Transgene Detail
Symbol: Tg(CMV-Abcc9)1Ajo
Name: transgene insertion 1, Aleksandar Jovanovic
MGI ID: MGI:3689050
Synonyms: CMV-SUR2A
Transgene: Tg(CMV-Abcc9)1Ajo  Location: unknown  
Strain of Origin:  (CBA x BALB/c)F2
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(CMV-Abcc9)1Ajo expresses 1 gene
Mutation detailsThis transgene consists of the full coding sequence of the mouse Abcc9 (Sur2a) gene under the control of the human cytomegalovirus immediate-early (CMV) promoter. RT-PCR and Western blot analysis confirmed an increase in mRNA and protein levels, respectively, resulting in an increased number of sarcolemmal KATP channels but not affecting the expression of any other KATP channel pore-forming proteins. (J:111456)
View phenotypes and curated references for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:111456 Du Q, et al., Overexpression of SUR2A generates a cardiac phenotype resistant to ischemia. FASEB J. 2006 Jun;20(8):1131-41
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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