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Targeted Allele Detail
Symbol: Spi1tm2.1Dgt
Name: spleen focus forming virus (SFFV) proviral integration oncogene; targeted mutation 2.1, Daniel G Tenen
MGI ID: MGI:3688440
Synonyms: PU.1-
Gene: Spi1  Location: Chr2:91082390-91115756 bp, + strand  Genetic Position: Chr2, 50.44 cM, cytoband E3
Germline Transmission:  Earliest citation of germline transmission: J:114150
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis allele is a derivative of Spfi1tm2Dgt in which the sequences flanked by loxP sites in introns 3 and 5 were deleted by Cre-mediated recombination in ES cells prior to the production of chimeric mice. (J:114150)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spi1 Mutation:  14 strains or lines available
Original:  J:114150 Iwasaki H, et al., Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation. Blood. 2005 Sep 1;106(5):1590-600
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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