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Apctm2.1Rak
Targeted Allele Detail
Nomenclature
Symbol: Apctm2.1Rak
Name: APC, WNT signaling pathway regulator; targeted mutation 2.1, Raju Kucherlapati
MGI ID: MGI:3688437
Synonyms: Apcdelta580
Gene: Apc  Location: Chr18:34220924-34322552 bp, + strand  Genetic Position: Chr18, 18.53 cM
Multiple intestinal neoplasia in Apctm2.1Rak/Apc+ mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:114152
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele is a derivative of Apctm2Rak in which the loxP-flanked exon 14 sequences have been deleted by Cre-mediated recombination in the germline. A single loxP site remains in place of exon 14 and flanking intronic sequences. Loss of exon 14 is predicted to introduce a frameshift mutation and a premature stop codon, resulting in a truncated protein. (J:114152)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apc Mutation:  58 strains or lines available
References
Original:  J:114152 Kuraguchi M, et al., Adenomatous Polyposis Coli (APC) is required for normal development of skin and thymus. PLoS Genet. 2006;2(9):e146
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory