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Targeted Allele Detail
Symbol: Il5tm1Anjm
Name: interleukin 5; targeted mutation 1, Andrew NJ McKenzie
MGI ID: MGI:3688245
Synonyms: IL-4/5/13KO
Gene: Il5  Location: Chr11:53720794-53725103 bp, + strand  Genetic Position: Chr11, 31.99 cM, cytoband A5/B1
Germline Transmission:  Earliest citation of germline transmission: J:113543
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsES cells previously targeted with the Il4/Il13tm3Anjm mutation were targeted with a second vector, incorporating a lacZ and hygro cassette into exon 3 of the interleukin 5 locus. Resulting ES cells had disruptions of the Il4, Il5 and Il13 genes. (J:113543)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il5 Mutation:  24 strains or lines available
Original:  J:113543 Fallon PG, et al., IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13. Immunity. 2002 Jul;17(1):7-17
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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