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Map2k6tm1Ina
Targeted Allele Detail
Nomenclature
Symbol: Map2k6tm1Ina
Name: mitogen-activated protein kinase kinase 6; targeted mutation 1, Izumi Nakashima
MGI ID: MGI:3687978
Synonyms: MKK6-
Gene: Map2k6  Location: Chr11:110399122-110525522 bp, + strand  Genetic Position: Chr11, 73.6 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:100093
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into exon 3, in the region encoding the kinase domain of the protein. RT-PCR analysis detects no transcript from the disrupted gene in thymocyte RNA from homozygous mutant mice. Immunoblot analysis detects no protein product from the targeted gene in thymocyte lysates from homozygous mutant mice and a reduced amount in lysates from heterozygous mutants. (J:100093)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Map2k6 Mutation:  23 strains or lines available
References
Original:  J:100093 Suzuki H, et al., Involvement of MKK6 in TCRalphabeta(int)CD69lo: a target population for apoptotic cell death in thymocytes. FASEB J. 2003 Aug;17(11):1538-40
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory