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Gbatm1.1Karl
Targeted Allele Detail
Nomenclature
Symbol: Gbatm1.1Karl
Name: glucosidase, beta, acid; targeted mutation 1.1, Stefan Karlsson
MGI ID: MGI:3687966
Synonyms: GCnull
Gene: Gba  Location: Chr3:89202928-89208966 bp, + strand  Genetic Position: Chr3, 39.01 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:113751
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
    Exons 9-11 were removed via cre mediated recombination in ES cells. (J:113751)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gba Mutation:  23 strains or lines available
References
Original:  J:113751 Enquist IB, et al., Effective cell and gene therapy in a murine model of Gaucher disease. Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13819-24
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory